Abstract
Multiple resistance to cytotoxic cancer drugs dramatically reduces the effectiveness of these drugs on many occasions. ABC (ATP-binding cassette) transporters pump out cytotoxic cancer drugs from cells, preventing them from reaching therapeutic levels. However, co-administration ABC transporter inhibitors with cytotoxic cancer drugs did not effectively improve the treatment outcome. The mechanisms and remedies are discussed.
MeSH terms
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ATP-Binding Cassette Transporters / antagonists & inhibitors
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ATP-Binding Cassette Transporters / metabolism
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ATP-Binding Cassette Transporters / physiology
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Animals
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use
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Drug Resistance, Neoplasm / drug effects
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Drug Resistance, Neoplasm / genetics
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Drug Resistance, Neoplasm / physiology*
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Humans
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Models, Biological
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Neoplasms / drug therapy*
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Neoplasms / metabolism
Substances
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ATP-Binding Cassette Transporters
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Antineoplastic Agents