Cryptococcal meningitis in a patient treated with infliximab

Patricia Muñoz; Maddalena Giannella; Maricela Valerio; Teresa Soria; Fernando Díaz; Javier Lopez Longo; Emilio Bouza

doi:10.1016/j.diagmicrobio.2006.10.014

Cryptococcal meningitis in a patient treated with infliximab

Diagn Microbiol Infect Dis. 2007 Apr;57(4):443-6. doi: 10.1016/j.diagmicrobio.2006.10.014. Epub 2007 Jan 19.

Authors

Patricia Muñoz¹, Maddalena Giannella, Maricela Valerio, Teresa Soria, Fernando Díaz, Javier Lopez Longo, Emilio Bouza

Affiliation

¹ Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, University of Madrid, 28007 Madrid, Spain. [email protected]

PMID: 17240111
DOI: 10.1016/j.diagmicrobio.2006.10.014

Abstract

Infliximab, a tumor necrosis factor-alpha inhibitor, is increasingly used for the therapy of different inflammatory conditions. We report the first case of cryptococcal meningitis in a patient treated with infliximab and other immunosuppressive agents, and review a further 5 reported cryptococcal infections. All of them involved fungal pneumonia. Outcome was favorable in all cases.

Publication types

Case Reports
Review

MeSH terms

Aged
Antibodies, Monoclonal / adverse effects*
Antibodies, Monoclonal / therapeutic use
Antirheumatic Agents / adverse effects*
Antirheumatic Agents / therapeutic use
Arthritis, Rheumatoid / drug therapy*
Arthritis, Rheumatoid / immunology
Female
Humans
Immunocompromised Host
Infliximab
Male
Meningitis, Cryptococcal / chemically induced*
Treatment Outcome
Tumor Necrosis Factor-alpha / antagonists & inhibitors

Substances

Antibodies, Monoclonal
Antirheumatic Agents
Tumor Necrosis Factor-alpha
Infliximab