Cardiovascular diseases are the major cause of mortality in Spain. This feature is related with the high prevalence of cardiovascular risk factors, particularly high blood pressure, dyslipidaemia, smoking, obesity and diabetes. Otherwise, the association of several risk factors, all related with cardio-metabolic risk, is the basis for the increase of individual global cardiovascular risk. We have studied prevalence of cardiovascular risk factors in several epidemiological studies in Spanish adult population, in nine autonomic communities and almost 15000 individuals. The principal objective was to evaluate the impact of obesity and overweight in the others cardiovascular risk factors in order to establish the relative weight of obesity in individual cardiovascular risk. With our results, this study presents a qualitative-quantitative model to calculate global cardiovascular risk in Spanish population according with the prevalence of different cardiovascular risk factors and the relative risk associated of every one in the same population.