Metabolic effects of protease inhibitor-sparing antiretroviral regimens given as initial treatment of HIV-1 Infection (AIDS Clinical Trials Group Study A5095)

J Acquir Immune Defic Syndr. 2007 Apr 15;44(5):540-50. doi: 10.1097/QAI.0b013e318031d5a0.

Abstract

Objective: To assess metabolic changes after initiation of protease inhibitor (PI)-sparing regimens in antiretroviral-naive patients.

Methods: Metabolic changes were analyzed within the triple-nucleoside (zidovudine [ZDV]/lamivudine [3TC]/abacavir [ABC])-containing, 3-drug efavirenz (EFV) [ZDV/3TC + EFV]-containing, and 4-drug EFV [ZDV/3TC/ABC + EFV]-containing arms of the AIDS Clinical Trials Group multicenter trial A5095. Metabolic values were compared with published US general population norms.

Results: From week 0 to week 24, all arms exhibited similar mild median increases in glucose and decreases in insulin sensitivity, whereas changes in lipids were greater in the ZDV/3TC + EFV and ZDV/3TC/ABC + EFV arms than in the ZDV/3TC/ABC arm: triglyceride (TG; 7, 18, and -1 mg/dL, respectively), total cholesterol (TC; 23, 28, and 5 mg/dL, respectively), low-density lipoprotein cholesterol (LDL-C; 9, 14, and 1 mg/dL, respectively), and high-density lipoprotein cholesterol (HDL-C; 10, 10, and 5 mg/dL, respectively). Adjusted mean study lipid values of all study participants at week 0 and week 96 compared with those of the National Health and Nutrition Examination Survey (NHANES) 1999 through 2002 values were: TG (148, 187, and 123 mg/dL, respectively), TC (164, 195, and 203 mg/dL, respectively), HDL-C (35, 47, and 51 mg/dL, respectively), and LDL-C (101, 117, and 123 mg/dL, respectively) (P < or = 0.005 for each value vs. NHANES values).

Conclusions: Similar mild increases in glucose and decreases in insulin sensitivity were observed in all regimens, whereas lipids were modestly higher in the EFV-containing arms. Compared with general population norms, the metabolic dysfunctions of concern after these PI-sparing therapies were increasingly abnormal TC and lower (but improved relative to baseline) HDL-C levels.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Alkynes
  • Anti-HIV Agents / administration & dosage
  • Anti-HIV Agents / adverse effects
  • Anti-HIV Agents / therapeutic use*
  • Antiretroviral Therapy, Highly Active
  • Benzoxazines / administration & dosage
  • Blood Glucose / metabolism
  • Body Composition / drug effects
  • Cyclopropanes
  • Dideoxynucleosides / administration & dosage
  • Double-Blind Method
  • Female
  • HIV Infections / drug therapy*
  • HIV Infections / metabolism*
  • HIV Infections / pathology
  • HIV-1
  • Humans
  • Insulin Resistance
  • Lactic Acid / blood
  • Lamivudine / administration & dosage
  • Lipids / blood
  • Male
  • Reverse Transcriptase Inhibitors / administration & dosage
  • Zidovudine / administration & dosage

Substances

  • Alkynes
  • Anti-HIV Agents
  • Benzoxazines
  • Blood Glucose
  • Cyclopropanes
  • Dideoxynucleosides
  • Lipids
  • Reverse Transcriptase Inhibitors
  • Lamivudine
  • Lactic Acid
  • Zidovudine
  • efavirenz
  • abacavir

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