Abstract
A facile six-step synthesis (15.2% yield) of ent-17beta-estradiol from readily accessible precursors is described. The preparation of analogues with 2-alkyl substituents, double bond unsaturation in the C-ring, a cis C,D-ring fusion and modified substituents at C(17) is also reported.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antioxidants / chemistry
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Antioxidants / metabolism
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Antioxidants / pharmacology
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Biochemistry / methods*
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Estradiol / analogs & derivatives
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Estradiol / chemical synthesis*
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Estradiol / chemistry*
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Estradiol / metabolism
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Ligands
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / metabolism
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Neuroprotective Agents / pharmacology
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Receptors, Estrogen / metabolism
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Antioxidants
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Ligands
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Neuroprotective Agents
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Receptors, Estrogen
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Estradiol