Possible joint origin of restless leg syndrome (RLS) and migraine

Behnam Sabayan; Mansooreh Bagheri; Afshin Borhani Haghighi

doi:10.1016/j.mehy.2006.10.060

Possible joint origin of restless leg syndrome (RLS) and migraine

Med Hypotheses. 2007;69(1):64-6. doi: 10.1016/j.mehy.2006.10.060. Epub 2007 Jan 26.

Authors

Behnam Sabayan¹, Mansooreh Bagheri, Afshin Borhani Haghighi

Affiliation

¹ Student Research Committee, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

PMID: 17258401
DOI: 10.1016/j.mehy.2006.10.060

Abstract

Sleep disorders have been described in migraine patients. Among sleep disorders RLS has been reported in up to one-third of migraineurs. Adverse effects of anti migraine therapy by dopamine antagonists can not fully explain this association. Therefore we present the hypothesis that RLS and migraine may have a joint origin. The hypothesis is supported by: (1) the same genetic origin for migraine without aura and RLS in single Italian family on chromosome 14q21; this gene codes survival motor neuron-interacting protein 1 (SIP1) which can play role in both diseases. (2) Correlation of both RLS and migraine with fibromyalgia. (3) Alteration of cortical excitability in both migraine and RLS.

MeSH terms

Comorbidity
Dopamine Antagonists / adverse effects*
Genetic Predisposition to Disease / epidemiology
Genetic Predisposition to Disease / genetics
Humans
Migraine Disorders / epidemiology
Migraine Disorders / etiology*
Migraine Disorders / genetics*
Models, Biological*
Restless Legs Syndrome / epidemiology
Restless Legs Syndrome / etiology*
Restless Legs Syndrome / genetics*

Substances

Dopamine Antagonists