Picking up the pieces: the roles of functional remnants of calpain-mediated proteolysis

David R Lynch; Amy J Gleichman

doi:10.1016/j.neuron.2007.01.014

Picking up the pieces: the roles of functional remnants of calpain-mediated proteolysis

Neuron. 2007 Feb 1;53(3):317-9. doi: 10.1016/j.neuron.2007.01.014.

Authors

David R Lynch¹, Amy J Gleichman

Affiliation

¹ Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. [email protected]

PMID: 17270728
DOI: 10.1016/j.neuron.2007.01.014

Abstract

Calpain-mediated cleavage of neuronal targets has long been associated with excitotoxicity and synaptic plasticity. In this issue of Neuron, two papers by Xu et al. and Abe and Takeichi explore the respective roles of mGluR1alpha cleavage in excitotoxicity and beta-catenin cleavage in transcriptional control. Together, these papers show the functional importance of fragments of calpain-mediated cleavage.

Publication types

Comment

MeSH terms

Animals
Calpain / metabolism*
Calpain / physiology*
Nervous System Diseases / enzymology*
Nervous System Diseases / physiopathology
Neuronal Plasticity / physiology
Phosphatidylinositol 3-Kinases / metabolism
Receptors, Metabotropic Glutamate / metabolism*
Signal Transduction / physiology
Transcription, Genetic
beta Catenin / metabolism*

Substances

Receptors, Metabotropic Glutamate
beta Catenin
metabotropic glutamate receptor type 1
Phosphatidylinositol 3-Kinases
Calpain