Abstract
Biochemical analysis of cultured fibroblasts obtained from human subjects with the autosomal dominant disorder familial hypercholesterolemia has led to the identification of a hitherto unrecognized cell-surface receptor for serum lipoproteins. This receptor plays a critical role in the physiologic regulation of cholesterol metabolism in human cells, and its absence leads to elevation of serum-cholesterol levels and severe atheroslerosis.
MeSH terms
-
Binding Sites
-
Cell Membrane / metabolism
-
Cells, Cultured
-
Cholesterol / biosynthesis*
-
Fibroblasts / drug effects
-
Fibroblasts / enzymology
-
Fibroblasts / metabolism*
-
Humans
-
Hydroxymethylglutaryl CoA Reductases / metabolism
-
Hypercholesterolemia / enzymology
-
Hypercholesterolemia / genetics*
-
In Vitro Techniques
-
Kinetics
-
Lipoproteins, LDL / metabolism*
-
Lipoproteins, LDL / pharmacology
-
Lipoproteins, VLDL / metabolism
Substances
-
Lipoproteins, LDL
-
Lipoproteins, VLDL
-
Cholesterol
-
Hydroxymethylglutaryl CoA Reductases