Experimental study on ultrasonic thermal chemotherapy for tumor treatment

Jingfbai Bai; Guoxin Ren; Yazhu Chen; Wei Guo

doi:10.1109/IEMBS.2005.1616061

Experimental study on ultrasonic thermal chemotherapy for tumor treatment

Conf Proc IEEE Eng Med Biol Soc. 2005:2005:6781-4. doi: 10.1109/IEMBS.2005.1616061.

Authors

Jingfbai Bai¹, Guoxin Ren, Yazhu Chen, Wei Guo

Affiliation

¹ Biomedical Instrument Institute, Shanghai Jiao Tong University, Shanghai, 200030, China.

PMID: 17281830
DOI: 10.1109/IEMBS.2005.1616061

Abstract

Ultrasound Thermal Chemotherapy (UTC) method was used to investigate the mechanism of apoptosis of tumor cells induced by ultrasound thermal therapy combined with thermosensitive drug in Mice Tumor Model (MTM). And the optimal parameters of ultrasonic, such as frequency, dose, sound field, treatment time and temperature, were found by the animal trials which the Tca8113 cells had been inoculated into the body of nude mice. Experimental results showed that the optimized thermal treatment technology of ultrasonic combined with the chemotherapy could produce obvious inhibitory effects of the tumor's growth. We also found that apoptosis reached its highest levels in the 6^thto 10^thhour, then gradually decreased and nearly resumed the normal level after the 12^thhour. UTC method could induce tumor cells to die significantly.