Abstract
We present the case of a 7-year-old boy who had a solitary mass within Meckel's cave that recurred 6 weeks after the initial resection. The histological, immunohistochemical, electron-microscopical, and molecular genetical features established the lesion's histiocytic nature. Our findings showed that it was closely related to juvenile xanthogranuloma, a benign lesion that usually occurs in the skin but has not yet been histologically confirmed in the brain. The present tumor is different from other intracranial histiocytic and xanthogranulomatous lesions.
MeSH terms
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Acid Phosphatase / analysis
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Actins / analysis
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Alkaline Phosphatase / analysis
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Antigens, CD / analysis
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Blotting, Southern
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Cell Transformation, Neoplastic / pathology
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Child
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Cranial Nerve Neoplasms / chemistry
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Cranial Nerve Neoplasms / pathology*
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Cranial Nerve Neoplasms / ultrastructure
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DNA, Neoplasm / analysis
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DNA, Neoplasm / genetics
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Gene Rearrangement, T-Lymphocyte / genetics
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Humans
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Immunohistochemistry
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Male
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Microscopy, Electron
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Skin Diseases / pathology*
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Trigeminal Ganglion*
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Xanthogranuloma, Juvenile / pathology*
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alpha 1-Antichymotrypsin / analysis
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alpha 1-Antitrypsin / analysis
Substances
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Actins
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Antigens, CD
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DNA, Neoplasm
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alpha 1-Antichymotrypsin
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alpha 1-Antitrypsin
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Alkaline Phosphatase
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Acid Phosphatase