Abstract
Introduction:
Fulminant hepatic encephalopathy has a high mortality.
Methods:
This case report describes the role of cerebral microdialysis as an adjunct to the management of a 49 - year-old woman with hepatic encephalopathy secondary to a paracetamol overdose.
Results:
The application of the microdialysis technique, by detecting a very low cerebral glucose concentration in the presence of a normal plasma glucose, assisted in clinical decision making.
Conclusions:
Cerebral microdialysis, by enabling continuous on-line monitoring of substrate delivery and metabolism, may have a role in the management of patients with fulminant hepatic failure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetaminophen / poisoning
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Analgesics, Non-Narcotic / poisoning
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Blood Glucose / metabolism
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Brain / physiopathology*
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Brain Edema / chemically induced
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Brain Edema / physiopathology*
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Brain Edema / therapy
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Critical Care*
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Dextropropoxyphene / poisoning
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Drug Combinations
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Drug Interactions
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Extracellular Fluid / physiology*
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Female
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Frontal Lobe / physiopathology
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Glucose / administration & dosage*
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Hepatic Encephalopathy / chemically induced
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Hepatic Encephalopathy / physiopathology*
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Hepatic Encephalopathy / therapy
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Humans
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Intracranial Pressure / drug effects
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Intracranial Pressure / physiology
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Lactic Acid / metabolism
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Liver Failure, Acute / chemically induced
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Liver Failure, Acute / physiopathology*
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Liver Failure, Acute / therapy
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Microdialysis*
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Middle Aged
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Pyruvic Acid / metabolism
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Risperidone / poisoning
Substances
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Analgesics, Non-Narcotic
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Blood Glucose
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Drug Combinations
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Lactic Acid
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Acetaminophen
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acetaminophen, dextropropoxyphene, drug combination
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Pyruvic Acid
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Glucose
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Risperidone
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Dextropropoxyphene