Abstract
A novel series of potent dual agonists of PPARalpha and PPARgamma, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure-activity relationships of this series of dual PPARalpha/gamma agonists are described.
MeSH terms
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Amino Acids / chemistry
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Amino Acids / pharmacology
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Animals
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Blood Glucose / drug effects
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Glycine / analogs & derivatives*
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Glycine / pharmacology*
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / pharmacology
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Hypolipidemic Agents / chemistry
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Hypolipidemic Agents / pharmacology
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Mice
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Mice, Inbred Strains
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PPAR alpha / agonists*
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PPAR gamma / agonists*
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Structure-Activity Relationship
Substances
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Amino Acids
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Blood Glucose
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Hypoglycemic Agents
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Hypolipidemic Agents
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PPAR alpha
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PPAR gamma
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Glycine