A radical role for p38 MAPK in tumor initiation

Cancer Cell. 2007 Feb;11(2):101-3. doi: 10.1016/j.ccr.2007.01.009.

Abstract

It is established that p38 MAPK can negatively regulate tumorigenesis, but the mechanism is incompletely understood. A new study in this issue of Cancer Cell shows that p38 MAP kinase plays a selective role in tumor initiation mediated by oxidative stress.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis
  • Cell Transformation, Neoplastic*
  • Humans
  • Mitogen-Activated Protein Kinase 14 / genetics
  • Mitogen-Activated Protein Kinase 14 / physiology*
  • Neoplasms / enzymology*
  • Neoplasms / pathology
  • Oxidative Stress*
  • Reactive Oxygen Species / metabolism
  • Signal Transduction

Substances

  • Reactive Oxygen Species
  • Mitogen-Activated Protein Kinase 14