Abstract
C-Acylations of polymer-supported 2-phosphoranylidene acetates ("linker reagents") with protected amino acids yielded 2-acyl-2-phosphoranylidene acetates as flexible intermediates for the C-terminal variation of carboxylic acids: peptidyl-2,3-diketoesters, peptidyl vinyl ketones, peptidyl-2-ketoaldehydes, and 1,3-diamino-2-hydroxy-propanes were obtained as products. [reaction: see text]
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / chemistry*
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Acylation
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Aldehydes / chemistry
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Carboxylic Acids / chemistry*
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Combinatorial Chemistry Techniques
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Cross-Linking Reagents / chemistry
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Diamines / chemistry
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Esters / chemistry
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Models, Chemical
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Peptides / chemical synthesis*
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Phosphoranes / chemistry*
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Polymers / chemistry*
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Resins, Synthetic / chemistry
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Vinyl Compounds / chemistry
Substances
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Acetates
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Aldehydes
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Carboxylic Acids
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Cross-Linking Reagents
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Diamines
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Esters
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Peptides
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Phosphoranes
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Polymers
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Resins, Synthetic
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Vinyl Compounds
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trimethylenediamine