Practical issues drawn from the implementation of the integrated test for Down syndrome screening into routine clinical practice

BJOG. 2007 Apr;114(4):493-7. doi: 10.1111/j.1471-0528.2007.01238.x. Epub 2007 Feb 19.

Abstract

We have evaluated a cohort of women booked for antenatal care at University College London Hospitals. The uptake of screening was 64.4% and was significantly higher (73 versus 46%) in women who booked before 14 weeks. Of the women who booked before 14 weeks, 96.8% opted for the integrated test (IT). Overall, 5.3% failed to attend for the second blood test. The false-positive rate in the women who had the IT was 2.9%. All 11 cases of Down syndrome were detected prenatally. Our study is the first to evaluate implementation of the IT into routine clinical practice.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Down Syndrome / diagnosis*
  • Female
  • Humans
  • Mass Screening / methods*
  • Mass Screening / statistics & numerical data
  • Nuchal Translucency Measurement
  • Patient Acceptance of Health Care
  • Pregnancy
  • Pregnancy-Associated Plasma Protein-A
  • Prenatal Diagnosis / methods*

Substances

  • Pregnancy-Associated Plasma Protein-A