Synthesis, oligonucleotide incorporation and base pair stability of 7-methyl-8-oxo-2'-deoxyguanosine

Org Biomol Chem. 2006 Nov 21;4(22):4068-70. doi: 10.1039/b612597b.

Abstract

7-Methyl-8-oxo-2'-deoxyguanosine, an analogue of the abundant promutagen 8-oxo-2'-deoxyguanosine, was incorporated into oligonucleotides and tested for its stability in various base pairs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Base Pairing
  • Deoxyguanosine / analogs & derivatives*
  • Deoxyguanosine / chemical synthesis
  • Deoxyguanosine / chemistry
  • Hydrogen Bonding
  • Molecular Structure
  • Oligonucleotides / chemistry*
  • Organophosphorus Compounds / chemical synthesis*
  • Organophosphorus Compounds / chemistry
  • Stereoisomerism

Substances

  • 7-methyl-8-oxo-2'-deoxyguanosine
  • Oligonucleotides
  • Organophosphorus Compounds
  • phosphoramidite
  • Deoxyguanosine