Abstract
Data on non-bacterial infections during allogeneic non-myeloablative hematopoietic stem cell transplantation (HSCT) are widely different. We evaluated data on 48 consecutive patients who received a conditioning regimen with fludarabine and cyclophosphamide (73%) or fludarabine and total body irradiation (27%) and then underwent allogeneic non-myeloablative HSCT. Cytomegalovirus (CMV) infection was common and occurred in 48% of patients; 3 patients developed CMV disease, and all survived. CMV reactivation was found to be common with both conditioning regimens in our patient population. Invasive aspergillosis occurred in 4 patients (8%) and 3 died. Other serious non-bacterial infections were uncommon. Review of the available literature on non-myeloablative HSCT suggests that the frequency and type of opportunistic infections vary considerably.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Academies and Institutes
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Antineoplastic Agents / administration & dosage
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Aspergillosis / epidemiology*
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Aspergillosis / etiology*
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Cyclophosphamide / administration & dosage
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Cytomegalovirus Infections / epidemiology*
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Cytomegalovirus Infections / etiology*
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Drug Therapy, Combination
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Female
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Hematopoietic Stem Cell Transplantation / adverse effects*
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Humans
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Immunosuppressive Agents / administration & dosage
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Male
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Michigan / epidemiology
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Middle Aged
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Myeloablative Agonists / administration & dosage
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Neoplasms / therapy
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Opportunistic Infections / epidemiology*
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Opportunistic Infections / etiology*
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Retrospective Studies
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Review Literature as Topic
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Transplantation Conditioning / adverse effects*
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Vidarabine / administration & dosage
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Vidarabine / analogs & derivatives
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Whole-Body Irradiation
Substances
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Antineoplastic Agents
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Immunosuppressive Agents
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Myeloablative Agonists
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Cyclophosphamide
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Vidarabine
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fludarabine