Abstract
To assess the effect of genetic factors on sporadic Parkinson disease, we performed a case-control study of a variant (G2385R) in Leucine-Rich Repeat kinase 2 among the Japanese population. The G2385R (c.7153G>A) variant was reported as a risk factor for sporadic Parkinson disease in the Chinese population from Taiwan and Singapore. Genotyping was conducted in 448 Parkinson disease patients and 457 healthy controls. The frequency of A allele in Parkinson disease was significantly higher than in the control (P=1.24x10(-4), odds ratio 2.63, 95% confidence interval 1.56-4.35). Our results suggest that the G2385R variant is a risk factor for sporadic Parkinson disease in the Asian population.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Asia / ethnology
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Brain / enzymology
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Brain / physiopathology
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Brain Chemistry / genetics*
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Cohort Studies
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DNA Mutational Analysis
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Female
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Gene Frequency
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Genetic Markers
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Genetic Predisposition to Disease / genetics*
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Genetic Testing
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Genotype
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Humans
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Japan / ethnology
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Male
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Middle Aged
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Mutation / genetics
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Parkinson Disease / enzymology*
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Parkinson Disease / ethnology
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Parkinson Disease / genetics*
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Protein Serine-Threonine Kinases / genetics*
Substances
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Genetic Markers
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LRRK2 protein, human
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Protein Serine-Threonine Kinases