F-16438s, novel binding inhibitors of CD44 and hyaluronic acid. II. Producing organism, fermentation, isolation, physico-chemical properties and structural elucidation

J Antibiot (Tokyo). 2006 Dec;59(12):777-84. doi: 10.1038/ja.2006.102.

Abstract

In the course of our screening for binding inhibitors of CD44 and hyaluronic acid, five active compounds, F-16438 A, B, E, F and G were found and isolated from the cultured broth of a fungal strain, Gloeoporus dichrous SANK 30502. The structures of these compounds except for F-16438 G were elucidated by physico-chemical and spectral data to be new compounds related to caloporoside; F-16438 G was identified to be the 6'-malonylated derivative of caloporoside.

MeSH terms

  • Fermentation*
  • Hyaluronan Receptors / metabolism*
  • Hyaluronic Acid / antagonists & inhibitors*
  • Hyaluronic Acid / metabolism
  • Magnetic Resonance Spectroscopy
  • Mannosides / chemistry
  • Mannosides / isolation & purification*
  • Molecular Conformation
  • Polyporales / metabolism*
  • Salicylates / chemistry
  • Salicylates / isolation & purification*

Substances

  • Hyaluronan Receptors
  • Mannosides
  • Salicylates
  • Hyaluronic Acid