Abstract
A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1. The resulting Phe655-->Cys substitution altered the sensitivity of glucan synthase to echinocandin drugs, consistent with a common mechanism for echinocandin resistance in Candida spp.
MeSH terms
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Amino Acid Sequence
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Anidulafungin
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Antifungal Agents / pharmacology*
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Candida / drug effects*
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Candida / enzymology
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Candida / genetics
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Caspofungin
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Drug Resistance, Fungal
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Echinocandins
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Glucosyltransferases / chemistry
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Glucosyltransferases / genetics*
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Lipopeptides
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Lipoproteins / pharmacology*
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Micafungin
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Peptides, Cyclic / pharmacology*
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Protein Subunits
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Lipoproteins
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Peptides, Cyclic
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Protein Subunits
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Anidulafungin
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Glucosyltransferases
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glucan synthase
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Caspofungin
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Micafungin