Abstract
Fosmidomycin-clindamycin therapy given every 12 h for 3 days was compared with a standard single oral dose of sulfadoxine-pyrimethamine. The two treatments showed comparably good tolerabilities and had an identical high degree of efficacy of 94% in a randomized trial carried out with 105 Gabonese children aged 3 to 14 years with uncomplicated malaria. These antimalarials merit further clinical exploration.
Publication types
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Antimalarials / therapeutic use*
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Child
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Child, Preschool
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Clindamycin / administration & dosage*
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Drug Combinations
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Female
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Fosfomycin / administration & dosage
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Fosfomycin / analogs & derivatives*
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Humans
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Malaria, Falciparum / drug therapy*
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Male
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Pyrimethamine / therapeutic use*
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Sulfadoxine / therapeutic use*
Substances
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Antimalarials
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Drug Combinations
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Fosfomycin
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fanasil, pyrimethamine drug combination
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Clindamycin
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fosmidomycin
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Sulfadoxine
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Pyrimethamine