Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP)

MeSH terms

• Acetylation
• Animals
• Antifungal Agents / chemical synthesis*
• Antifungal Agents / chemistry
• Antifungal Agents / therapeutic use
• Candidiasis / drug therapy*
• Echinocandins
• Humans
• Mice
• Mice, Inbred DBA
• Microbial Sensitivity Tests
• Peptides / chemical synthesis*
• Peptides / chemistry
• Peptides / therapeutic use
• Peptides, Cyclic*
• Pneumonia, Pneumocystis / drug therapy*
• Prodrugs / chemical synthesis*
• Prodrugs / chemistry
• Prodrugs / therapeutic use
• Rats
• Rats, Inbred Strains