Abstract
The first complexes containing both a sulfur atom and a hydroxamate moiety coordinated to a biologically relevant transition metal were synthesized as models for the structure of inhibited peptide deformylases. Two of these [(N(2)S)Zn(hydroxamate)] complexes were characterized by X-ray crystallography. The first contains a thioether and a simple hydroxamate, the second a thiolate and a N-substituted hydroxamate. Isolation of a complex with a thiolate and a simple hydroxamate group was not possible.
MeSH terms
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Amidohydrolases / antagonists & inhibitors*
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Crystallography, X-Ray
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Hydrolysis
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Hydroxamic Acids / chemical synthesis
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Hydroxamic Acids / chemistry*
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Hydroxamic Acids / pharmacology*
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Models, Molecular
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Protease Inhibitors / chemistry*
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Protease Inhibitors / pharmacology*
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Solvents
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Sulfur Compounds / chemistry*
Substances
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Hydroxamic Acids
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Indicators and Reagents
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Protease Inhibitors
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Solvents
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Sulfur Compounds
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Amidohydrolases
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peptide deformylase