Abstract
Vaccines with synthetic peptides induce the immune response to epitopes that bind to several HLA alleles. By using a TEPITOPE algorithm, we selected and analyzed the T-cell responses of peripheral blood mononuclear cells from 29 paracoccidioidomycosis (PCM) patients to peptides of the immunodominant gp43 antigen of Paracoccidioides brasiliensis, the causative agent of PCM.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Fungal / immunology*
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Cells, Cultured
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Fungal Proteins / immunology*
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Glycoproteins / immunology*
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Humans
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Paracoccidioides / immunology*
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Paracoccidioidomycosis / immunology*
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Paracoccidioidomycosis / microbiology
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Peptides / immunology*
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T-Lymphocytes / immunology*
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T-Lymphocytes / microbiology
Substances
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43 kDa protein, Paracoccidioides
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Antigens, Fungal
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Fungal Proteins
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Glycoproteins
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Peptides