The rate of epidemiological and virological changes during the transition from nascent to concentrated HIV epidemic stage in the former Soviet Union countries

AIDS Res Hum Retroviruses. 2007 Feb;23(2):183-92. doi: 10.1089/aid.2006.0006.

Abstract

The rate of processes accompanying the transition of the HIV-1 epidemic from nascent stage to concentrated one in the Former Soviet Union (FSU) during intravenous drug user (IDU)-associated HIV infection outbreaks in 1994-1999 has not been analyzed. To define the rates, we studied susceptible populations and circulating viruses before, during, and after the outbreaks. Our findings included the following: (1) the pattern of high HIV-1 genetic diversity characteristic of the nascent epidemic changed to a concentrated one within 1 year in St. Petersburg and in Moscow; (2) different FSU regions were at different stages of the HIV-1 epidemic in 1994-1996; (3) the change of serotypic patterns characteristic of different stages of the HIV/AIDS epidemic for the non-IDU risk group occurred within 1 year in Moscow, suggesting an extremely high rate of IDU-associated epidemic pattern distributions in regions and susceptible populations in the FSU.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / classification
  • Acquired Immunodeficiency Syndrome / epidemiology*
  • Acquired Immunodeficiency Syndrome / genetics
  • Disease Outbreaks*
  • Female
  • Genetic Variation*
  • HIV Seropositivity / epidemiology
  • HIV Seroprevalence / trends*
  • HIV-1 / genetics*
  • Humans
  • Male
  • Molecular Sequence Data
  • Phylogeny
  • Risk Factors
  • Russia / epidemiology
  • Substance Abuse, Intravenous / virology

Associated data

  • GENBANK/AF502142
  • GENBANK/AY766029
  • GENBANK/AY766036
  • GENBANK/AY766037
  • GENBANK/AY766038
  • GENBANK/AY766061
  • GENBANK/AY766062
  • GENBANK/AY766063
  • GENBANK/AY766064
  • GENBANK/AY766070
  • GENBANK/AY766071
  • GENBANK/AY766072
  • GENBANK/AY766073
  • GENBANK/AY766074
  • GENBANK/AY766075
  • GENBANK/AY766076
  • GENBANK/AY766077
  • GENBANK/U40283
  • GENBANK/U40284
  • GENBANK/U40285
  • GENBANK/U40319
  • GENBANK/U40320
  • GENBANK/U40321
  • GENBANK/U40322
  • GENBANK/U40323
  • GENBANK/U40324
  • GENBANK/U40325
  • GENBANK/U40326
  • GENBANK/U40327
  • GENBANK/U40328
  • GENBANK/U40329
  • GENBANK/U40330