In the frame of IDEA project, a research programme has been carried out to study the potential of the reconstruction of numerical anthropomorphic phantoms based on personal physiological data obtained by computed tomography (CT) and Magnetic Resonance Imaging (MRI) for calibration in in vivo monitoring. As a result, new procedures have been developed taking advantage of recent progress in image processing codes that allow, after scanning and rapidly reconstructing a realistic voxel phantom, to convert the whole measurement geometry into computer file to be used on line for MCNP (Monte Carlo N-Particule code) calculations. The present paper overviews the major abilities of the OEDIPE software studies made in the frame of the IDEA project, on the examples of calibration for lung monitoring as well as whole body counting of a real patient.