Abstract
So far, only one variant translocation of the t(11;18)(q21;q21), the t(11;12;18) (q21;q13;q21), has been reported. We herein describe two new variant translocations, the t(6;18;11)(q24;q21;q21) and the t(11;14;18)(q21;q32;q21), occurring in mucosa-associated lymphoid tissue (MALT) lymphomas. In both cases, fluorescence in situ hybridization (FISH) and reverse transcriptase polymerase chain reaction (RT-PCR) revealed the presence of an 5'API2-3'MALT1 fusion product, encoded on the derivative chromosome 11. Exon 7 of API2 was fused with exon 5 of MALT1 in the t(11;14;18) and with exon 8 of MALT1 in the t(6;18;11). FISH revealed the involvement of the immunoglobulin locus in the t(11;14;18). Rapid amplification of cDNA ends (RACE)-PCR to detect the involved partner gene on 6q showed exclusively wild-type API2 and MALT1 sequences.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Chromosomes, Human, Pair 11 / genetics*
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Chromosomes, Human, Pair 11 / ultrastructure
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Chromosomes, Human, Pair 14 / genetics*
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Chromosomes, Human, Pair 14 / ultrastructure
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Chromosomes, Human, Pair 18 / genetics*
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Chromosomes, Human, Pair 18 / ultrastructure
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Chromosomes, Human, Pair 6 / genetics*
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Chromosomes, Human, Pair 6 / ultrastructure
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Computer Systems
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Exons / genetics*
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Genes, Immunoglobulin
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Humans
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In Situ Hybridization, Fluorescence
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Karyotyping
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Lung Neoplasms / genetics
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Lymphoma, B-Cell, Marginal Zone / genetics*
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Male
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Middle Aged
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Neoplasm Recurrence, Local
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Oncogene Proteins, Fusion / genetics*
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Reverse Transcriptase Polymerase Chain Reaction
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Stomach Neoplasms / genetics
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Translocation, Genetic*
Substances
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API2-MALT1 fusion protein, human
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Oncogene Proteins, Fusion