Abstract
Investigation of antiinflammatory constituents of the stem and root barks of Ulmus davidiana var. japonica resulted in the isolation of three guaiane type sesquiterpenes, torilin, 1-hydroxytorilin, together with a new derivative, (1beta, 7beta, 8beta, 10beta)-1,8,11-trihydroxy-4-guaien-8-angeloyl-3-one named 1-hydroxytorilin A. All the three sesquiterpenes inhibited lipopolysaccharide-induced nitric oxide production in murine microglial BV2 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / pharmacology*
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Anti-Inflammatory Agents / therapeutic use
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Cells, Cultured
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Dose-Response Relationship, Drug
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Lipopolysaccharides
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Mice
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Nitric Oxide / antagonists & inhibitors*
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Nitric Oxide / biosynthesis*
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Roots
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Plant Stems
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Sesquiterpenes / administration & dosage
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Sesquiterpenes / pharmacology
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Sesquiterpenes / therapeutic use
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Ulmus*
Substances
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Anti-Inflammatory Agents
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Lipopolysaccharides
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Plant Extracts
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Sesquiterpenes
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Nitric Oxide