[Studies on using spray drying technique in preparing Ophiopogon japonicus saponin enteric microsphere by orthogonal experimental design]

Lan Shen; Yi Feng; De-sheng Xu; Xiao Lin

[Studies on using spray drying technique in preparing Ophiopogon japonicus saponin enteric microsphere by orthogonal experimental design]

Zhongguo Zhong Yao Za Zhi. 2006 Dec;31(23):1947-50.

[Article in Chinese]

Authors

Lan Shen¹, Yi Feng, De-sheng Xu, Xiao Lin

Affiliation

¹ Shanghai University of traditional Chinese medicine, Shanghai 201203, China.

PMID: 17348185

Abstract

Objective: To explore the best technique parameters on preparing ophiopogon japonicus saponin enteric microsphere by spray drying technique.

Method: The best technique parameters were investigated by orthogonal experimental design and by the target, such as surface appearances, encapsulated efficiency, etc.

Result: The best technique parameters included the inlet temperature (90 degrees C ), the feeding speed (10 mL x min(- 1)), and the rotate speed of atomizer (50 r x min(-1)).

Conclusion: Ophiopogon japonicus saponin enteric microsphere accorded with the expecting demand. The main influencing factor was inlet temperature . It is suitable to industrialize in preparing Traditional Chinese Medicine microsphere.

Publication types

English Abstract

MeSH terms

Drug Compounding / methods*
Microscopy, Electron
Microspheres*
Ophiopogon / chemistry*
Plants, Medicinal / chemistry
Saponins / chemistry
Saponins / isolation & purification*
Tablets, Enteric-Coated / chemistry
Temperature

Substances

Saponins
Tablets, Enteric-Coated