Prognostic factors in Hungarian breast cancer patients

Anticancer Res. 2007 Jan-Feb;27(1A):279-82.

Abstract

Background: Breast cancer is the most common cancer among women, with variable outcomes, justifying a continuous search for new parameters to predict accurate prognosis and indicate suitable adjuvant therapy for patients.

Materials and methods: Fourty-four stage I-III breast cancer specimens were investigated immunohistochemically for the expression of cyclooxygenase-2 enzyme (COX-2), hormone receptors, tumor suppressor gene p53, oncogene HER2 and proliferation marker Ki-67. Additionally, twelve specimens were also investigated for the presence of the phosphorylated extracellular signal-regulated kinase (pERK).

Results: It was demonstrated that expressions of biological markers were related to each other (ER to p53 and Ki-67, COX-2 to ER, PgR, Ki-67 and p53, Ki-67 to p53 and PgR, p53 to PgR).

Conclusion: Our data indicate that concomitant immunohistochemical evaluation of cyclooxygenase-2, hormone receptors, p53 and Ki-67 may be of clinical value in determining an accurate prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms / enzymology*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology*
  • Cyclooxygenase 2 / biosynthesis
  • Extracellular Signal-Regulated MAP Kinases / metabolism
  • Female
  • Humans
  • Hungary
  • Immunohistochemistry
  • Ki-67 Antigen / biosynthesis
  • Middle Aged
  • Neoplasm Staging
  • Phosphorylation
  • Prognosis
  • Receptor, ErbB-2 / genetics
  • Receptor, ErbB-2 / metabolism
  • Receptors, Estrogen / biosynthesis
  • Receptors, Progesterone / biosynthesis

Substances

  • Ki-67 Antigen
  • Receptors, Estrogen
  • Receptors, Progesterone
  • Cyclooxygenase 2
  • Receptor, ErbB-2
  • Extracellular Signal-Regulated MAP Kinases