High CSF neurofilament heavy chain levels in neuromyelitis optica

Neurology. 2007 Mar 13;68(11):865-7. doi: 10.1212/01.wnl.0000256820.26489.17.

Abstract

The neurofilament heavy chain (NfHSMI35), a biomarker of axonal damage in the CSF, was measured in patients with neuromyelitis optica (NMO) and multiple sclerosis (MS). Significantly high CSF NfHSMI35 levels (>0.73 ng/mL) were found in 6 of 24 (25%) of the patients with NMO but none of the patients with MS (0/24). This finding suggests that axonal damage is more severe in NMO than in MS.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biomarkers / cerebrospinal fluid
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neurofilament Proteins / cerebrospinal fluid*
  • Neuromyelitis Optica / cerebrospinal fluid*
  • Neuromyelitis Optica / diagnosis
  • Retrospective Studies

Substances

  • Biomarkers
  • Neurofilament Proteins