[A case of advanced breast cancer with multiple liver metastases resistant to chemotherapy responding to high-dose toremifene]

Chizuru Matsumoto; Takashi Ishikawa; Nobuyoshi Momiyama; Takashi Chishima; Yasushi Ichikawa; Shinji Togo; Kenji Inui; Hiroshi Shimada

[A case of advanced breast cancer with multiple liver metastases resistant to chemotherapy responding to high-dose toremifene]

Gan To Kagaku Ryoho. 2007 Mar;34(3):449-51.

[Article in Japanese]

Authors

Chizuru Matsumoto¹, Takashi Ishikawa, Nobuyoshi Momiyama, Takashi Chishima, Yasushi Ichikawa, Shinji Togo, Kenji Inui, Hiroshi Shimada

Affiliation

¹ Dept. of General Surgery, Yokohama City University Medical Center.

PMID: 17353641

Abstract

A 47-year-old woman was admitted to our hospital for advanced breast cancer with multiple liver metastases and liver dysfunction in January 2004. EC (EPI combined with CPA), weekly PTX, and AI were performed but were not effective for that tumor. Therefore, high-dose TOR was started. Liver dysfunction recovered after administration of TOR, and primary tumor and liver metastases were evaluated as a partial response (PR). The same therapy has been performed for six months with no evidence of deterioration.

Publication types

Case Reports

MeSH terms

Anastrozole
Antineoplastic Agents, Hormonal / administration & dosage*
Breast Neoplasms / drug therapy*
Breast Neoplasms / pathology
Carcinoma / drug therapy*
Carcinoma / secondary
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Resistance, Neoplasm*
Female
Humans
Liver Neoplasms / drug therapy
Liver Neoplasms / physiopathology
Liver Neoplasms / secondary*
Middle Aged
Nitriles / pharmacology
Quality of Life
Remission Induction
Toremifene / administration & dosage*
Triazoles / pharmacology

Substances

Antineoplastic Agents, Hormonal
Nitriles
Triazoles
Anastrozole
Toremifene