Chronic intestinal pseudoobstruction with myopathy and ophthalmoplegia. A muscular biochemical study of a mitochondrial disorder

Dig Dis Sci. 1992 Mar;37(3):456-63. doi: 10.1007/BF01307743.

Abstract

The association of chronic intestinal pseudoobstruction with ophthalmoplegia has been reported previously in visceral myopathies. We report a case of this association in which muscle mitochondria had a crystalline appearance, a dense core, and decreased cytochrome c oxidase and succinate cytochrome c reductase activities. The absence of evident mitochondrial DNA deletion in the skeletal muscle of this patient does not exclude the possibility of localized deletion or mutation of mitochondrial DNA in digestive muscle.

Publication types

  • Case Reports

MeSH terms

  • Chronic Disease
  • DNA / analysis
  • Humans
  • Intestinal Pseudo-Obstruction / complications
  • Intestinal Pseudo-Obstruction / enzymology
  • Intestinal Pseudo-Obstruction / genetics
  • Intestinal Pseudo-Obstruction / pathology*
  • Jejunal Diseases / complications
  • Jejunal Diseases / enzymology
  • Jejunal Diseases / genetics
  • Jejunal Diseases / pathology*
  • Male
  • Middle Aged
  • Mitochondria, Muscle / enzymology
  • Mitochondria, Muscle / ultrastructure*
  • Muscular Diseases / enzymology
  • Muscular Diseases / genetics
  • Muscular Diseases / pathology*
  • Ophthalmoplegia / complications
  • Ophthalmoplegia / pathology*
  • Syndrome

Substances

  • DNA