Abstract
We used 123I-Ioflupane SPECT to study striatal dopamine transporter (DAT) binding in 36 Parkinson's disease (PD) patients with history of severe occupational exposure to hydrocarbons. Data were compared with 38 PD patients without exposure history as well as healthy controls. Both PD cohorts showed significant striatal uptake decrements compared with controls. We found significantly lower values in the whole striatum of exposed compared with non-exposed patients (0.83 +/- 0.25 vs. 1.05 +/- 0.39; P = 0.004), more pronounced in the putamen (0.61 +/- 0.24 vs. 0.85 +/- 0.42; P = 0.004). We conclude that severe occupational exposure to hydrocarbons may modify disease course and ultimately accelerate nigro-striatal denervation.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aged
-
Binding, Competitive / drug effects
-
Binding, Competitive / physiology
-
Corpus Striatum / diagnostic imaging
-
Corpus Striatum / drug effects
-
Corpus Striatum / metabolism*
-
Disease Progression
-
Dopamine / metabolism
-
Dopamine Plasma Membrane Transport Proteins / drug effects
-
Dopamine Plasma Membrane Transport Proteins / metabolism*
-
Female
-
Humans
-
Hydrocarbons / toxicity*
-
Male
-
Middle Aged
-
Nerve Degeneration / chemically induced
-
Nerve Degeneration / metabolism
-
Nerve Degeneration / physiopathology
-
Nortropanes* / pharmacokinetics
-
Occupational Exposure*
-
Parkinson Disease / diagnosis*
-
Parkinson Disease / etiology*
-
Parkinson Disease / physiopathology
-
Tomography, Emission-Computed, Single-Photon
Substances
-
Dopamine Plasma Membrane Transport Proteins
-
Hydrocarbons
-
Nortropanes
-
ioflupane
-
Dopamine