Effects of delta sleep-inducing peptide on pre- and postsynaptic glutamate and postsynaptic GABA receptors in neurons of the cortex, hippocampus, and cerebellum in rats

Bull Exp Biol Med. 2006 Aug;142(2):186-8. doi: 10.1007/s10517-006-0323-9.
[Article in English, Russian]

Abstract

We studied the effect of delta sleep-inducing peptide on GABA receptors of hippocampal and cerebellar neurons in rats. It was shown that delta sleep-inducing peptide considerably and dose-dependently potentiates GABA-activated currents in these neurons and blocks NMDA-activated potentiation in cortical and hippocampal neurons. The peptide modulates activity of presynaptic NMDA receptors, which is seen from changes in (45)Ca(2+) uptake into synaptosomes of the brain cortex after uptake stimulation with glutamate and NMDA.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / drug effects*
  • Brain / metabolism
  • Calcium Radioisotopes / metabolism
  • Delta Sleep-Inducing Peptide / pharmacology*
  • Dose-Response Relationship, Drug
  • Neurons / drug effects*
  • Neurons / metabolism
  • Rats
  • Rats, Wistar
  • Receptors, GABA / metabolism*
  • Receptors, Glutamate / metabolism*
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Synaptosomes / metabolism

Substances

  • Calcium Radioisotopes
  • Receptors, GABA
  • Receptors, Glutamate
  • Receptors, N-Methyl-D-Aspartate
  • Delta Sleep-Inducing Peptide