Abstract
Small interfering RNAs targeting the conserved RNA termini upstream of NP and L gene were found to reduce reporter gene expression from Lassa virus replicon and Lassa virus mRNA expression construct and to inhibit replication of different Lassa virus strains, lymphocytic choriomeningitis virus, and Mopeia virus in cell culture.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiviral Agents / pharmacology*
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Base Sequence
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Chlorocebus aethiops
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Conserved Sequence*
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Humans
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Lassa Fever / virology
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Lassa virus / drug effects*
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Lassa virus / genetics
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Lassa virus / metabolism
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Lassa virus / physiology
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Molecular Sequence Data
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Nucleoproteins / chemistry
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Nucleoproteins / genetics
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Nucleoproteins / metabolism
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RNA Interference*
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RNA, Small Interfering / chemistry
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RNA, Small Interfering / genetics
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RNA, Small Interfering / metabolism
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RNA, Small Interfering / pharmacology*
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RNA, Viral / chemistry*
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RNA, Viral / genetics
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RNA, Viral / metabolism
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Vero Cells
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Viral Proteins / chemistry
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Viral Proteins / genetics
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Viral Proteins / metabolism
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Virus Replication / drug effects
Substances
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Antiviral Agents
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Nucleoproteins
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RNA, Small Interfering
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RNA, Viral
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Viral Proteins