Good for Goose, but not for Gander: IL-2 interferes with Th17 differentiation

Brigitta Stockinger

doi:10.1016/j.immuni.2007.03.001

Good for Goose, but not for Gander: IL-2 interferes with Th17 differentiation

Immunity. 2007 Mar;26(3):278-9. doi: 10.1016/j.immuni.2007.03.001.

Author

Brigitta Stockinger¹

Affiliation

¹ Division of Molecular Immunology, The MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK. [email protected]

PMID: 17376391
DOI: 10.1016/j.immuni.2007.03.001

Abstract

In this issue of Immunity, Laurence et al. (2007) examined the effects of interleukin-2 on differentiation of the T helper 17 (Th17) cells and found that this essential growth factor for all other T cell subsets blocks the development of Th17 T cells.

Publication types

Comment
Review

MeSH terms

Animals
Cell Differentiation / drug effects
Interleukin-17 / metabolism*
Interleukin-2 / pharmacology
Interleukin-2 / physiology*
Mice
T-Lymphocytes, Helper-Inducer / drug effects
T-Lymphocytes, Helper-Inducer / immunology*

Substances

Interleukin-17
Interleukin-2