Estimation of macular pigment optical density in the elderly: test-retest variability and effect of optical blur in pseudophakic subjects

Vision Res. 2007 Apr;47(9):1253-9. doi: 10.1016/j.visres.2007.01.013. Epub 2007 Mar 21.

Abstract

The reproducibility of macular pigment optical density (MPOD) estimates in the elderly was assessed in 40 subjects (age: 79.1+/-3.5). Test-retest variability was good (Pearson's r coefficient: 0.734), with an average coefficient of variation (CV) of 18.4% and an intraclass correlation coefficient (ICC) of 0.96. The effect of optical blur on MPOD estimates was investigated in 22 elderly pseudophakic subjects (age: 79.9+/-3.6) by comparing the baseline MPOD, obtained with an optimal correction, with MPODs obtained with a +/-1.00-diopter optical blur. This optical blur did not cause differences in the MPOD estimates, its accuracy, or test duration.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Diagnostic Techniques, Ophthalmological
  • Female
  • Humans
  • Macula Lutea / chemistry
  • Male
  • Middle Aged
  • Optics and Photonics
  • Photometry / methods
  • Pseudophakia / physiopathology*
  • Reproducibility of Results
  • Retinal Pigments / analysis*
  • Visual Acuity

Substances

  • Retinal Pigments