Abstract
Three commonly used Mycobacterium bovis BCG vaccine strains elicited different magnitudes of T-cell activation and gamma interferon production in vitro in healthy BCG-vaccinated individuals. Glaxo 1077 exhibited the greatest stimulatory capacity, followed by Pasteur 1173 and then Danish 1331. These differences may affect in vitro stimulation and vaccination-induced immunogenicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Bacterial / biosynthesis
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BCG Vaccine / immunology
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BCG Vaccine / pharmacology*
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Humans
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Interferon-gamma / biosynthesis*
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Interferon-gamma / metabolism
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Lymphocyte Activation / drug effects*
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Mycobacterium bovis / classification
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Mycobacterium bovis / immunology
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Mycobacterium bovis / physiology*
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T-Lymphocytes / drug effects*
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T-Lymphocytes / immunology
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T-Lymphocytes / physiology
Substances
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Antibodies, Bacterial
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BCG Vaccine
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Interferon-gamma