Clinical xenotransplantation of organs: why aren't we there yet?

Muhammad M Mohiuddin

doi:10.1371/journal.pmed.0040075

Clinical xenotransplantation of organs: why aren't we there yet?

PLoS Med. 2007 Mar 27;4(3):e75. doi: 10.1371/journal.pmed.0040075.

Author

Muhammad M Mohiuddin¹

Affiliation

¹ Cardiothoracic Surgery Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America. [email protected]

Abstract

Mohiuddin discusses the lessons learned from large animal xenograft models and why the immunological barrier is still the most important hurdle preventing clinical xenotransplantation of organs.

MeSH terms

Animals
Animals, Genetically Modified
Graft Rejection
Graft Survival
Humans
Islets of Langerhans Transplantation / methods
Organ Transplantation / methods*
Organ Transplantation / trends
Swine
Transplantation, Heterologous / methods*
Transplantation, Heterologous / trends