Inhibition of myc promoter and telomerase activity and induction of delayed apoptosis by SYUIQ-5, a novel G-quadruplex interactive agent in leukemia cells

Leukemia. 2007 Jun;21(6):1300-2. doi: 10.1038/sj.leu.2404652. Epub 2007 Mar 29.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects
  • DNA
  • Diamines / pharmacology*
  • G-Quadruplexes
  • Genes, myc / drug effects
  • Humans
  • Leukemia / drug therapy*
  • Leukemia / pathology*
  • Promoter Regions, Genetic / drug effects
  • Quinolines / pharmacology*
  • Telomerase / drug effects

Substances

  • Antineoplastic Agents
  • Diamines
  • N'-(10H-indolo(3,2-b)quinolin-11-yl)-N,N-dimethylpropane-1,3-diamine
  • Quinolines
  • DNA
  • Telomerase