Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity

Emily M Stocking; Jennifer M Miller; Ann J Barbier; Sandy J Wilson; Jamin D Boggs; Heather M McAllister; Jiejun Wu; Timothy W Lovenberg; Nicholas I Carruthers; Ronald L Wolin

doi:10.1016/j.bmcl.2007.03.034

Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity

Bioorg Med Chem Lett. 2007 Jun 1;17(11):3130-5. doi: 10.1016/j.bmcl.2007.03.034. Epub 2007 Mar 15.

Authors

Emily M Stocking¹, Jennifer M Miller, Ann J Barbier, Sandy J Wilson, Jamin D Boggs, Heather M McAllister, Jiejun Wu, Timothy W Lovenberg, Nicholas I Carruthers, Ronald L Wolin

Affiliation

¹ Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. [email protected]

PMID: 17412583
DOI: 10.1016/j.bmcl.2007.03.034

Abstract

The synthesis and structure-activity relationships of a series of novel phenoxyphenyl diamine derivatives with affinity for both the histamine H(3) receptor and the serotonin transporter is described.

MeSH terms

Diamines / chemistry*
Histamine Antagonists / chemical synthesis
Histamine Antagonists / chemistry*
Histamine Antagonists / pharmacology*
Humans
Molecular Structure
Receptors, Histamine H3 / chemistry
Receptors, Histamine H3 / drug effects*
Selective Serotonin Reuptake Inhibitors / chemical synthesis
Selective Serotonin Reuptake Inhibitors / chemistry*
Selective Serotonin Reuptake Inhibitors / pharmacology*
Structure-Activity Relationship

Substances

Diamines
Histamine Antagonists
Receptors, Histamine H3
Serotonin Uptake Inhibitors