Abstract
The synthesis of a new series of 1beta-methylcarbapenems having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIIi) having 2-methyl-[1,2,6]thiadiazinan-1,1-dioxide moiety showed the most potent antibacterial activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Carbapenems / chemical synthesis*
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Carbapenems / chemistry
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Carbapenems / pharmacology*
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Drug Evaluation, Preclinical
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Spectrophotometry, Ultraviolet
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Spectroscopy, Fourier Transform Infrared
Substances
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Anti-Bacterial Agents
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Carbapenems