A unique case of IgD-only splenic marginal-zone lymphoma with mutated immunoglobulin genes: ontogenetic implications

Theodora Papadaki; Kostas Stamatopoulos; Theodore Mavrommatis; Achilles Anagnostopoulos; Dimitra Anagnostou

doi:10.1016/j.leukres.2007.03.013

A unique case of IgD-only splenic marginal-zone lymphoma with mutated immunoglobulin genes: ontogenetic implications

Leuk Res. 2008 Jan;32(1):155-7. doi: 10.1016/j.leukres.2007.03.013. Epub 2007 Apr 8.

Authors

Theodora Papadaki¹, Kostas Stamatopoulos, Theodore Mavrommatis, Achilles Anagnostopoulos, Dimitra Anagnostou

Affiliation

¹ Hemopathology Department, Evangelismos Hospital, Athens, Greece.

PMID: 17420049
DOI: 10.1016/j.leukres.2007.03.013

Abstract

Splenic marginal zone lymphoma (SMZL) is a rare indolent lymphoma subtype which accounts for less than 1% of all non-Hodgkin's lymphomas. We here report a unique case of IgD-only SMZL with mutated immunoglobulin variable region genes and discuss possible ontogenetic derivation.

Publication types

Case Reports

MeSH terms

Aged
Female
Genes, Immunoglobulin*
Humans
Immunoglobulin D / metabolism*
Immunoglobulin Variable Region / genetics*
Immunohistochemistry
Lymphoma, B-Cell, Marginal Zone
Mutation
Splenic Neoplasms / genetics*

Substances

Immunoglobulin D
Immunoglobulin Variable Region