Task-related differential dynamics of EEG alpha- and beta-band synchronization in cortico-basal motor structures

Eur J Neurosci. 2007 Mar;25(5):1604-15. doi: 10.1111/j.1460-9568.2007.05417.x.

Abstract

Movement-related processing results in the modulation of neuronal synchronization over several electroencephalography (EEG) frequency ranges, including alpha- (8-12 Hz) and beta-band (14-30 Hz). Whether modulation patterns differ across sites within the motor system remains unclear, but could denote how information is conveyed across the cortico-basal network. We therefore compared the event-related synchronization/desynchronization (ERS/ERD) in recordings from the scalp, basal ganglia and thalamic structures during a motor task. Simultaneous depth and scalp EEG were recorded in 13 patients, undergoing deep brain stimulation of the thalamic ventral intermediate nucleus (VIM) or the subthalamic nucleus (STN). They performed a choice-reaction task with pre-cued Go-signals, instructive for either left- or right-sided button presses. In the beta-band, pre-cues and Go-signals were followed by ERD starting well before and peaking at task execution, uniformly in all cortical and subcortical recordings. In contrast, a comparable alpha-band ERD was only seen at the scalp, whereas mirror-like ERS were observed in the motor-inhibitory STN. In VIM, which receives strong somatosensory afferences, a major alpha-ERD upon the Go-signal did not start until the motor response. These dissociations of task-related Alpha- and Beta-band dynamics tag a functional diversity in cortico-basal networks, which are simultaneously active in motor processing. Whereas the uniform downregulation of Beta-activity points to an anti-kinetic operation mode throughout the motor system, site-dependent courses of Alpha-synchronization rather reflect the coordination of activity levels in functionally divergent motor structures during the preparation and execution of movements.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alpha Rhythm
  • Beta Rhythm
  • Brain Mapping
  • Choice Behavior / physiology*
  • Cortical Synchronization
  • Deep Brain Stimulation / methods
  • Electroencephalography*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Motor Cortex / physiopathology*
  • Movement Disorders / physiopathology*
  • Movement Disorders / surgery
  • Nonlinear Dynamics*
  • Psychomotor Performance / physiology
  • Psychomotor Performance / radiation effects
  • Reaction Time / physiology
  • Reaction Time / radiation effects