White matter changes in Leber's hereditary optic neuropathy: MRI findings

Eur J Neurol. 2007 May;14(5):591-3. doi: 10.1111/j.1468-1331.2007.01757.x.

Abstract

Leber's hereditary optic neuropathy is a mitochondrial disorder causing bilateral optic nerve degeneration. It is sometimes associated with clinical signs of multiple sclerosis. We report MRI findings in two patients with LHON-MS and comment on possible distinguishing features of this disease entity.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain / pathology*
  • Brain / physiopathology
  • Diagnosis, Differential
  • Disease Progression
  • Early Diagnosis
  • Female
  • Gait Disorders, Neurologic / etiology
  • Gait Disorders, Neurologic / pathology
  • Gait Disorders, Neurologic / physiopathology
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Multiple Sclerosis / pathology
  • Multiple Sclerosis / physiopathology
  • Nerve Fibers, Myelinated / pathology*
  • Optic Atrophy, Hereditary, Leber / diagnosis*
  • Optic Atrophy, Hereditary, Leber / pathology
  • Optic Atrophy, Hereditary, Leber / physiopathology
  • Optic Nerve / pathology*
  • Optic Nerve / physiopathology
  • Predictive Value of Tests
  • Sensation Disorders / etiology
  • Sensation Disorders / pathology
  • Sensation Disorders / physiopathology
  • Vision, Low / etiology
  • Vision, Low / pathology
  • Vision, Low / physiopathology