The radiologist's role in managing paediatric liver transplantation: personal experience with 40 patients

Radiol Med. 2007 Apr;112(3):456-71. doi: 10.1007/s11547-007-0128-6. Epub 2007 Apr 20.
[Article in English, Italian]

Abstract

Purpose: The aim of our study was to evaluate the radiologist's role in managing paediatric orthotopic liver transplantation (OLT) through a retrospective review of our experience in diagnosing and treating post-OLT complications.

Materials and methods: Forty children (mean age 4.6 years) underwent 44 OLTs over 71 months. The follow-up period (mean 724 days) was divided into three phases: hospital stay, up to three months after discharge and subsequent period. The number and type of radiological examinations, radiologically detectable complications and interventional procedures were analysed.

Results: Most examinations were carried out with ultrasound (US) (859/931 of all radiological studies performed during the first two phases, 92.3%). Colour-Doppler US enabled early detection and treatment of all vascular complications (9/40, 22.5% of patients; 13 complications in nine patients, eight arterial and five portal complications; 1.4 for each patient with complications). Computed tomography (CT) or angiography was very rarely employed. US also detected biliary complications (11 patients, 27.5%: three cases of segmental ducts excluded from the anastomosis, four cases of stenosis of the biliodigestive anastomosis, one lithiasis, three stenoses associated with lithiasis), which were successfully managed in 75% of the cases treated with interventional radiology procedures (percutaneous bilioplasty and/or lithotripsy). At the time of writing this paper, the patient survival rate was 100%, and the organ survival rate was 91% (40/44). There were four re-transplantations: three due to hepatic artery thrombosis and one to biliary stenosis with lithiasis.

Conclusions: The radiologist's role is fundamental for early sonographic diagnosis of post-OLT complications in children. Vascular complications are often associated in a single patient, and early treatment may improve the prognosis. Interventional radiology represents a safe and effective treatment for many biliary complications.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adolescent
  • Age Factors
  • Angiography
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Graft Survival
  • Humans
  • Infant
  • Liver Transplantation / adverse effects
  • Liver Transplantation / diagnostic imaging*
  • Liver Transplantation / mortality
  • Male
  • Postoperative Complications / diagnostic imaging*
  • Postoperative Complications / therapy
  • Reoperation
  • Retrospective Studies
  • Survival Analysis
  • Time Factors
  • Tomography, X-Ray Computed
  • Ultrasonography, Doppler*