Abstract
Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes--PPARgamma, SOS2, and PCK1--with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender.
(c) 2007 Wiley-Liss, Inc.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP-Binding Cassette Transporters / genetics
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Age of Onset
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Aged
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Aged, 80 and over
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Alzheimer Disease / epidemiology
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Alzheimer Disease / genetics*
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Female
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Gene Frequency
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Genetic Predisposition to Disease*
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Haplotypes
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Humans
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Insulin / genetics*
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Intracellular Signaling Peptides and Proteins / genetics*
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Male
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PPAR gamma / genetics*
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Phosphoenolpyruvate Carboxykinase (GTP) / genetics*
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Polymorphism, Single Nucleotide / genetics
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Potassium Channels / genetics
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Potassium Channels, Inwardly Rectifying / genetics
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Receptors, Drug / genetics
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Sex Characteristics
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Signal Transduction / genetics*
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Son of Sevenless Proteins / genetics*
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Sulfonylurea Receptors
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United Kingdom / epidemiology
Substances
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ATP-Binding Cassette Transporters
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Insulin
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Intracellular Signaling Peptides and Proteins
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PPAR gamma
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Potassium Channels
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Potassium Channels, Inwardly Rectifying
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Receptors, Drug
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SOS2 protein, human
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Son of Sevenless Proteins
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Sulfonylurea Receptors
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PCK1 protein, human
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Phosphoenolpyruvate Carboxykinase (GTP)