Abstract
The onset of protection after the administration of a modified-live bovine viral diarrhea virus (BVDV) vaccine was determined. Protection was determined following experimental infection with a virulent type-2 BVDV (strain 1373) in cattle vaccinated 3, 5, or 7 days before BVDV infection. Protection, as measured by reduced virus shedding, lack of leukopenia, reduction in viremia, and reduced mortality, was present as early as 3 days after vaccination with a single dose of modified-live BVDV vaccine. Complete protection was obtained in cattle vaccinated 5 or 7 days before BVDV experimental infection.
Publication types
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Viral / blood
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Bovine Virus Diarrhea-Mucosal Disease / immunology
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Bovine Virus Diarrhea-Mucosal Disease / prevention & control*
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Cattle
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Cattle Diseases / immunology
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Cattle Diseases / prevention & control*
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Diarrhea Virus 2, Bovine Viral / immunology*
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Injections, Subcutaneous
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Male
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Vaccines, Attenuated / administration & dosage
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Vaccines, Attenuated / therapeutic use
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Viral Vaccines / administration & dosage
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Viral Vaccines / therapeutic use*
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Virus Shedding
Substances
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Antibodies, Viral
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Vaccines, Attenuated
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Viral Vaccines