Age has no effect on de novo constitutional t(11;22) translocation frequency in sperm

Fertil Steril. 2007 Nov;88(5):1446-8. doi: 10.1016/j.fertnstert.2007.01.019. Epub 2007 Apr 19.

Abstract

We analyzed de novo constitutional t(11;22) translocation frequency in sperm derived from normal healthy males as a function of the age of the sperm donors (from 25 to 51). Translocation-specific polymerase chain reaction demonstrated no age-dependent increment in the frequency of the rearrangements.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aging / genetics*
  • Humans
  • Male
  • Middle Aged
  • Spermatozoa / physiology*
  • Translocation, Genetic / genetics*